Fire crews were called to the derelict buildings at Gateforth Park, Thorpe Willoughby shortly before 10:20 hrs on Saturday morning.
It is understood that damage to the site was substantial, with a 1,000 square metre building completely destroyed in the blaze.
North Yorkshire Fire & Rescue have confirmed that five crews attended the fire.
The former mushroom farm suffered a similar arson attack on March 20.
